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Resolution of damaged tissue requires mesenchymal cells to attach to collagen fibers through integrin-dependent mechanisms and generate mechanical tension via the actin cytoskeleton to promote tissue contraction and wound size reduction
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Finally, low glutamine in the core region of solid tumors led to histone hypermethylation due to decreased -ketoglutarate level, resulting in cell dedifferentiation and therapeutic resistance in melanoma cells [64]
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